Recombinant Rat Pepsinogen C / PGC Protein (His tag) 20µg
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Catalog numberPKSR030364-20µg
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Price:
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Size20µg
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SynonymPG1;Pg-1;Upg1
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ActivityNA
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SequenceMet 1-Val 392
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Fusion tagC-His
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AccessionNP_579818.1
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ExpressedHostHEK293 Cells
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ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity> 95 % as determined by SDS-PAGE
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Endotoxin< 1.0 EU per μg of the protein as determined by the LAL method
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Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass42.5 kDa
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AP Mol Mass43 KDa
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FormulationLyophilized from sterile 50mM Tris, 150mM NaCl, pH 7.5
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BackgroundPepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.
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Conjugationhistidine
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AboutRats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin nameRattus norvegicus
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolPGC, PPARGC1A
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Short nameRecombinant Pepsinogen C / PGC Protein (His tag) 20µg
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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HostRat
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LabelHis
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SpeciesRat, Rats
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Alternative nameRec. Rat Pepsinogen C / PGC Protein (histidine detection labelled) 20µg
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameprogastricsin
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Synonyms gene name
- progastricsin (pepsinogen C)
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Synonyms name
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Classification
- Pepsinogens
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namePPARG coactivator 1 alpha
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Synonyms gene
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Synonyms gene name
- peroxisome proliferative activated receptor, gamma, coactivator 1
- peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
- peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-08-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- RNA binding motif containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data