Recombinant Rat Pepsinogen C / PGC Protein (His tag) 20µg

#

• Catalog number
  PKSR030364-20µg
• Price:

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• Size
  20µg

# #

• Synonym
  PG1;Pg-1;Upg1
• Activity
  NA
• Sequence
  Met 1-Val 392
• Fusion tag
  C-His
• Accession
  NP_579818.1
• ExpressedHost
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 95 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  42.5 kDa
• AP Mol Mass
  43 KDa
• Formulation
  Lyophilized from sterile 50mM Tris, 150mM NaCl, pH 7.5
• Background
  Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.
• Technical Data
• Conjugation
  histidine
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

#

• Gene target
  Pepsinogen   PGC   Protein   His   tag   20µg  
• Gene symbol
  PGC, PPARGC1A
• Short name
  Recombinant Pepsinogen C / PGC Protein (His tag) 20µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  Rat
• Label
  His
• Species
  Rat, Rats
• Alternative name
  Rec. Rat Pepsinogen C / PGC Protein (histidine detection labelled) 20µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:8890
• Gene
  PGC
• Long gene name
  progastricsin
• Synonyms gene name
  • progastricsin (pepsinogen C)
• Synonyms name
  • pepsinogen C
• Locus
  6p21.1
• Discovery year
  2001-06-22
• Entrez gene record
  5225
• Classification
  • Pepsinogens
• VEGA ID
  OTTHUMG00000014683

Gene info

• Identity
  HGNC:9237
• Gene
  PPARGC1A
• Long gene name
  PPARG coactivator 1 alpha
• Synonyms gene
  • PPARGC1
• Synonyms gene name
  • peroxisome proliferative activated receptor, gamma, coactivator 1
  • peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
• Synonyms
  • PGC1
  • PGC1A
  • PGC-1alpha
• Synonyms name
  • PPARgamma coactivator 1alpha
• GenBank acession
  • AF106698
• Locus
  4p15.2
• Discovery year
  1999-08-02
• Entrez gene record
  10891
• Pubmed identfication
  • 10585775
• RefSeq identity
  • NM_013261
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000097747

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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