Recombinant Mouse CD200R4 / CD200 Receptor 4 / CD200RLa Protein (His tag) 100µg
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Catalog numberPKSM040571-100µg
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Price:
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Size100µg
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ActivityNA
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SynonymCd200r4;F630107N04Rik;MCD200RLa
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SequenceMet 1-Thr 241
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Fusion tagC-His
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AccessionNP_997127.1
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Expressed HostHEK293 Cells
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ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity> 96 % as determined by SDS-PAGE
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Endotoxin< 1.0 EU per μg of the protein as determined by the LAL method
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Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass25 kDa
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AP Mol Mass50-60 kDa
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FormulationLyophilized from sterile PBS, pH 7.4
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BackgroundCell surface glycoprotein CD200 receptor 4, also known as Cell surface glycoprotein OX2 receptor 4, CD200 cell surface glycoprotein receptor-like 4, CD200RLa, and CD200R4, is a single-pass type I membrane protein which belongs to the CD200R family. CD200 (OX2) is a cell surface glycoprotein that interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. In mouse there are up to five genes related to CD200R with conflicting data as to whether they bind CD200. CD200R4 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. CD200R4 is highly expressed in monocytes, NK cells and a subset of NKT cells. It is weakly expressed in granulocytes and B cells (at protein level). CD200R4 is also expressed in brain, lung, testis, thymus, intestine and uterus. and in bone marrow derived-macrophage and dendritic cells and mast cells. CD200R4 is involved in the recruitment or surface expression of the TYROBP receptor.
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Conjugationhistidine
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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DescriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolCD200
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Short nameRecombinant Mouse CD200R4 / CD200 Receptor 4 / CD200RLa Protein (His tag) 100µg
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TechniqueRecombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Hostmouse
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LabelHis
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SpeciesMouse, Mouses
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Alternative nameRec. Mouse CD200R4 / CD200 molecule Receptor 4 / CD200RLa Protein (histidine detection labelled) 100µg
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Alternative techniquerec, murine
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Alternative to gene targetCD200 molecule, MOX1 and MOX2 and MRC and OX-2, CD200 and IDBG-49799 and ENSG00000091972 and 4345, protein binding, Plasma membranes, Cd200 and IDBG-162936 and ENSMUSG00000022661 and 17470, CD200 and IDBG-632279 and ENSBTAG00000033319 and 534910
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Gene info
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Identity
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Gene
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Long gene nameCD200 molecule
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Synonyms gene
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Synonyms gene name
- antigen identified by monoclonal antibody MRC OX-2
- CD200 antigen
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Synonyms
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Classification
- CD molecules
- Immunoglobulin like domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data