Recombinant Human CD200 / OX-2 Protein (His & Fc tag) 100µg
-
Catalog number
PKSH031374-100µg
-
Price
Please ask
-
Size
100µg
-
-
Synonym
MOX1;MOX2;MRC;OX-2;OX2
-
Activity
Measured by its binding ability in a functional ELISA. Immobilized human CD200R1 at 1 μg/ml (100 μl/well) can bind human CD200 Fc Chimera with a linear range of 0.12-16 ng/ml.
-
Sequence
Met 1-Gly 232
-
Fusion tag
C-His & Fc
-
Accession
NP_005935.4
-
Expressed Host
HEK293 Cells
-
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
-
Purity
＞95 % as determined by SDS-PAGE
-
Endotoxin
＜1.0 EU per µg as determined by the LAL method
-
Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Mol Mass
50.5 kDa
-
AP Mol Mass
65-70 kDa
-
Formulation
Lyophilized from sterile PBS, pH 7.4
-
Reconstitution
Please refer to it for detailed information.
-
Background
CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in a number of human malignancies. In addition, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
-
-
-
Conjugation
histidine
-
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
CD200, HCRT, TNFSF4, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2, RNU6-2
-
Short name
Recombinant CD200 / OX-2 Protein (His & Fc tag) 100µg
-
Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
-
Label
His
-
Species
Human, Humans
-
Alternative name
Rec. H. sapiens CD200 molecule / OX-2 Protein (histidine & fragment c detection labelled) 100µg
-
Alternative technique
rec
-
Alternative to gene target
CD200 molecule, MOX1 and MOX2 and MRC and OX-2, CD200 and IDBG-49799 and ENSG00000091972 and 4345, protein binding, Plasma membranes, Cd200 and IDBG-162936 and ENSMUSG00000022661 and 17470, CD200 and IDBG-632279 and ENSBTAG00000033319 and 534910
-
Gene info
-
Identity
-
Gene
-
Long gene name
CD200 molecule
-
Synonyms gene
-
Synonyms gene name
- antigen identified by monoclonal antibody MRC OX-2
- CD200 antigen
-
Synonyms
-
Locus
-
Discovery year
2001-06-22
-
Entrez gene record
-
Classification
- CD molecules
- Immunoglobulin like domain containing
-
VEGA ID
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
TNF superfamily member 4
-
Synonyms gene
-
Synonyms gene name
- tax-transcriptionally activated glycoprotein 1, 34kD
- tumor necrosis factor (ligand) superfamily, member 4
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
1993-12-15
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Tumor necrosis factor superfamily
- CD molecules
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene name
microRNA 1289-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year
2008-11-03
-
Entrez gene record
-
RefSeq identity
-
Classification
Gene info
-
Identity
-
Gene
-
Long gene name
microRNA 521-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year
2005-07-15
-
Entrez gene record
-
RefSeq identity
-
Classification
Gene info
-
Identity
-
Gene
-
Long gene name
microRNA 509-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year
2007-10-24
-
Entrez gene record
-
RefSeq identity
-
Classification
Gene info
-
Identity
-
Gene
-
Long gene name
microRNA 512-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year
2005-07-15
-
Entrez gene record
-
RefSeq identity
-
Classification
Gene info
-
Identity
-
Gene
-
Long gene name
microRNA 7-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year
2004-04-23
-
Entrez gene record
-
RefSeq identity
-
Classification
Gene info
-
Identity
-
Gene
-
Long gene name
microRNA 329-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year
2005-07-11
-
Entrez gene record
-
RefSeq identity
-
Classification
Gene info
-
Identity
-
Gene
-
Long gene name
RNA, U6 small nuclear 2
-
Synonyms
-
Locus
-
Discovery year
2008-06-10
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
