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Recombinant Human CD200 / OX-2 Protein (His tag) 100µg

  • Catalog number
    PKSH031373-100µg
  • Product name
    Recombinant Human CD200 / OX-2 Protein (His tag) 100µg
  • Size
    100µg
  • Synonym
    MOX1;MOX2;MRC;OX-2;OX2
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200 at 1 μg/ml (100 μl/well) can bind human CD200R1 / Fc Chimera with a linear range of 0.12-16 ng/ml.
  • Sequence
    Met 1-Gly 232
  • Fusion tag
    C-His
  • Accession
    NP_005935.4
  • Expressed Host
    HEK293 Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    ＞98 % as determined by SDS-PAGE
  • Endotoxin
    ＜1.0 EU per µg as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    24 kDa
  • AP Mol Mass
    40-45 kDa
  • Formulation
    Lyophilized from sterile PBS, pH 7.4
  • Reconstitution
    Please refer to it for detailed information.
  • Background
    CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in a number of human malignancies. In addition, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
  • Product URL
    Product_URL
  • PDF URL
    PDF_URL
  • Alternative to gene target
    • [ "CD200 molecule", "MOX1 and MOX2 and MRC and OX-2", "CD200 and IDBG-49799 and ENSG00000091972 and 4345", "protein binding", "Plasma membranes", "Cd200 and IDBG-162936 and ENSMUSG00000022661 and 17470", "CD200 and IDBG-632279 and ENSBTAG00000033319 and 534910" ]
  • Gene target
    CD200 / OX-2 Protein His tag 100µg
    • Gene info
    Gene info
    Gene info
    Gene info
    Gene info
    Gene info
    Gene info
    Gene info
    Gene info
    Gene info
  • Gene symbol
    CD200, HCRT, TNFSF4, MIR7-2, MIR329-2, MIR512-2, MIR521-2, MIR1289-2, MIR509-2, KRTAP13-2
  • Short name
    Recombinant CD200 / OX-2 Protein (His tag) 100µg
  • Label
    His
  • label filter
    • His
  • technique filter
    • Recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Alternative technique
    rec