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Stock availabilitIn Stock
In Stock
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CAS number
208260-29-1
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Description
c-Raf kinase inhibitor
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Molecular weight
389,4 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C23H23N3O3
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Origin
Synthetic
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Purity pourcentage
≥95% (HPLC)
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Soluble in
Soluble in DMSO (200 mg/ml)
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Physical appearance
White to off-white solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Acute toxicity, Oral (Category 5) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H303 May be harmful if swallowed.
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PubChem number
5730
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Scientific context
ZM 336372 is a potent, specific and reversible inhibitor of the protein kinase c-Raf. It has also been shown to inhibit SAPK2/p38. ZM 336372 is cell permeable.
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Bibliography
1. Hall-Jackson C.A., et al. (1999) Chem. Biol. 6(8): 559–568.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of ZM 336372 (SIH-488), a c-Raf kinase inhibitor. CAS #: 208260-29-1. Molecular Formula: C23H23N3O3. Molecular Weight: 389.4 g/mol. Chemical structure of ZM 336372, a c-Raf kinase inhibitor (SIH-488). CAS # 208260-29-1. Molecular Formula: C23H23N3O3.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
