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Stock availabilitIn Stock
In Stock
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CAS number
1163719-91-2
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Description
RAF Inhibitor
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Molecular weight
541,63 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-(methylthio)-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C28H27N7O3S
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Origin
Synthetic
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Purity pourcentage
98%
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Soluble in
Soluble in DMSO
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Physical appearance
White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Blue Ice or 4ºC
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
Refer to PubChem
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Scientific context
CCT241161, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant tumors. It is active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.03µM and 0.01µM for BRAF kinase and SRC kinase respectively.
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Bibliography
1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.
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Release date
2-Sep-2015
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of CCT241161 (SIH-186), a RAF Inhibitor. CAS #: 1163719-91-2. Molecular Formula: C28H27N7O3S. Molecular Weight: 541.63 g/mol. Chemical structure of CCT241161, a RAF Inhibitor (SIH-186). CAS # 1163719-91-2. Molecular Formula: C28H27N7O3S.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
