CCT196969, RAF Inhibitor
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Catalog numberSIH-185-10MG
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Price:
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Size10 mg
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Stock availabilitIn StockIn Stock
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CAS number1163719-56-9
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DescriptionRAF Inhibitor
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Molecular weight513,53 g/mol
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Primary research fieldsCancer, Apoptosis
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Other name1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea, CCT-196969, CCT 196969
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC27H24FN7O3
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OriginSynthetic
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Purity pourcentage96%
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Soluble inSoluble in DMSO
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Physical appearanceWhite Solid
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Storage recommendations-20ºC
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Shipping recommendationsBlue Ice or 4ºC
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Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem numberRefer to PubChem
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Scientific contextCCT196969, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant melanoma tumors. It is also active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.1µM and 0.03µM for BRAF kinase and SRC kinase respectively.
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Bibliography1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.
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Release date2-Sep-2015
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of CCT196969 (SIH-185), a RAF Inhibitor. CAS #: 1163719-56-9. Molecular Formula: C27H24FN7O3. Molecular Weight: 513.53 g/mol. Chemical structure of CCT196969, a RAF Inhibitor (SIH-185). CAS # 1163719-56-9. Molecular Formula: C27H24FN7O3.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.01
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolRAF1
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Short nameCCT196969, RAF Inhibitor
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Alternative nameCCT196969, RAF suppressor
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Gene info
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Identity
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Gene
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Long gene nameRaf-1 proto-oncogene, serine/threonine kinase
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Synonyms gene name
- v-raf-1 murine leukemia viral oncogene homolog 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Mitogen-activated protein kinase kinase kinases
- RAF family
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VEGA ID
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Locus Specific Databases