CCT196969, RAF Inhibitor

  • Catalog number
    SIH-185-10MG
  • Price
    Please ask
  • Size
    10 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    1163719-56-9
  • Description
    RAF Inhibitor
  • Molecular weight
    513,53 g/mol
  • Primary research fields
    Cancer, Apoptosis
  • Other name
    1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea, CCT-196969, CCT 196969
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C27H24FN7O3
  • Origin
    Synthetic
  • Purity pourcentage
    96%
  • Soluble in
    Soluble in DMSO
  • Physical appearance
    White Solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Blue Ice or 4ºC
  • Safety information
    Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
  • PubChem number
    Refer to PubChem
  • Scientific context
    CCT196969, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant melanoma tumors. It is also active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.1µM and 0.03µM for BRAF kinase and SRC kinase respectively.
  • Bibliography
    1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.
  • Release date
    2-Sep-2015
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of CCT196969 (SIH-185), a RAF Inhibitor. CAS #: 1163719-56-9. Molecular Formula: C27H24FN7O3. Molecular Weight: 513.53 g/mol. Chemical structure of CCT196969, a RAF Inhibitor (SIH-185). CAS # 1163719-56-9. Molecular Formula: C27H24FN7O3.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.01
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    RAF1
  • Short name
    CCT196969, RAF Inhibitor
  • Alternative name
    CCT196969, RAF suppressor
Gene info
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