BAY 11 7082, IKK kinase inhibitor
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Catalog numberSIH-434-10MG
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PricePlease ask
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Size10 mg
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Stock availabilitIn StockIn Stock
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CAS number19542-67-7
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DescriptionIKK kinase inhibitor
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Molecular weight207,3 g/mol
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Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other nameBay 11-7821, (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC10H9NO2S
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OriginSynthetic
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Purity pourcentage≥98% (HPLC)
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Soluble inSoluble to 25 mM in ethanol and to 100 mM in DMSO
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Physical appearanceWhite solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number5353431
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Scientific contextBAY 11 7082 inhibits cytokine induced IκBα phosphorylation and indirectly decreases NF-κb activity. It is also an E2 ubiquitin (Ub) conjugating enzyme inhibitor. BAY 11 7082 can also induce apoptosis.
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Bibliography1. Mori N., et al. (2002) Blood 100(5): 1828–1834. 2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103.
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Release date1-Oct-2014
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of BAY 11 7082 (SIH-434), a IKK kinase inhibitor. CAS #: 19542-67-7. Molecular Formula: C10H9NO2S. Molecular Weight: 207.3 g/mol. Chemical structure of BAY 11 7082, a IKK kinase inhibitor (SIH-434). CAS # 19542-67-7. Molecular Formula: C10H9NO2S.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.01
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolIKBKE, IKBKB, CHUK, IKBKG
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Short nameBAY 11 7082, IKK kinase inhibitor
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Alternative nameBAY 11 7082, IKK phosphorylation catalyst suppressor
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Gene info
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Identity
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Gene
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Long gene nameinhibitor of nuclear factor kappa B kinase subunit epsilon
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Synonyms gene name
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-12-02
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Entrez gene record
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Pubmed identfication
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Classification
- I kappa B kinases
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinhibitor of nuclear factor kappa B kinase subunit beta
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Synonyms gene name
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-02-11
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Entrez gene record
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Pubmed identfication
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Classification
- I kappa B kinases
- IKK complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namecomponent of inhibitor of nuclear factor kappa B kinase complex
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Synonyms gene
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Synonyms gene name
- conserved helix-loop-helix ubiquitous kinase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-03-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- I kappa B kinases
- IKK complex
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinhibitor of nuclear factor kappa B kinase regulatory subunit gamma
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Synonyms gene
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Synonyms gene name
- incontinentia pigmenti
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
- inhibitor of nuclear factor kappa B kinase subunit gamma
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-09-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zinc fingers C2HC-type
- IKK complex
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VEGA ID
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Locus Specific Databases