IKK epsilon, Kinase Inhibitor II[IKK epsilon, Kinase Inhibitor II]

Products_type

Inhibitor
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

IKK epsilon Kinase Inhibitor II[IKK epsilon Kinase Inhibitor II]
Gene symbol

IKBKE, IKBKB, CHUK, IKBKG
Short name

IKK epsilon, Kinase Inhibitor II[IKK epsilon, Kinase Inhibitor II]
Alternative name

IKK epsilon, phosphorylation catalyst suppressor II[IKK epsilon, phosphorylation catalyst suppressor II]

Identity

HGNC:14552
Gene

IKBKE
Long gene name

inhibitor of nuclear factor kappa B kinase subunit epsilon
Synonyms gene name
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Synonyms
- IKKE
- IKK-i
- KIAA0151
GenBank acession
- AB016590
Locus

1q32.1
Discovery year

2002-12-02
Entrez gene record

9641
Pubmed identfication
- 10421793
- 10882136
Classification
- I kappa B kinases
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000184613

Identity

HGNC:5960
Gene

IKBKB
Long gene name

inhibitor of nuclear factor kappa B kinase subunit beta
Synonyms gene name
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Synonyms
- IKK2
- NFKBIKB
- IKK-beta
- IKKB
GenBank acession
- AF029684
Locus

8p11.21
Discovery year

1998-02-11
Entrez gene record

3551
Pubmed identfication
- 9878263
- 9763654
- 18308615
Classification
- I kappa B kinases
- IKK complex
VEGA ID

OTTHUMG00000164092
Locus Specific Databases
- LRG_1241

Identity

HGNC:1974
Gene

CHUK
Long gene name

component of inhibitor of nuclear factor kappa B kinase complex
Synonyms gene
- TCF16
Synonyms gene name
- conserved helix-loop-helix ubiquitous kinase
Synonyms
- IKK1
- IKK-alpha
- IkBKA
- NFKBIKA
- IKKA
Synonyms name
- inhibitor of nuclear factor kappa-B kinase subunit alpha
- I-kappa-B kinase
GenBank acession
- AF009225
Locus

10q24.31
Discovery year

1995-03-15
Entrez gene record

1147
Pubmed identfication
- 7558004
- 16902410
RefSeq identity
- NM_001278
Classification
- I kappa B kinases
- IKK complex
VEGA ID

OTTHUMG00000018899

Identity

HGNC:5961
Gene

IKBKG
Long gene name

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Synonyms gene
- IP2
- IP1
Synonyms gene name
- incontinentia pigmenti
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
- inhibitor of nuclear factor kappa B kinase subunit gamma
Synonyms
- IKK-gamma
- NEMO
- Fip3p
- FIP-3
- FIP3
- ZC2HC9
- IKKAP1
- IKKG
Synonyms name
GenBank acession
- AF074382
Locus

Xq28
Discovery year

1998-09-30
Entrez gene record

8517
Pubmed identfication
- 9751060
- 10087442
- 11590134
- 11242109
RefSeq identity
- NM_003639
Classification
- Zinc fingers C2HC-type
- IKK complex
VEGA ID

OTTHUMG00000024234
Locus Specific Databases