Auranofin, IKK kinase inhibitor
-
Catalog numberSIH-493-50MG
-
PricePlease ask
-
Size50 mg
-
-
Stock availabilitIn StockIn Stock
-
CAS number34031-32-8
-
DescriptionIKK kinase inhibitor
-
Molecular weight678,5 g/mol
-
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
-
Other name1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate, 3,4,5-Triacetyloxy-6-(acetyloxymethyl) oxane-2-thiolate triethylphosphanium, SKF 39162
-
Product categorySmall Molecules
-
Product typeInhibitor
-
Chemical formulaC20H34AuO9PS
-
OriginSynthetic
-
Purity pourcentage≥98% (HPLC)
-
Soluble inSoluble in DMSO (5 mg/ml) or 100% ethanol (4 mg/ml)
-
Physical appearanceWhite solid
-
Storage recommendations-20ºC
-
Shipping recommendationsShipped Ambient
-
Safety informationClassification: Acute toxicity, Oral (Category 3), H301 Reproductive toxicity (Category 2), H361 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H361 Suspected of damaging fertility or the unborn child. Precautionary statements: P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P281 Use personal protective equipment as required. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
-
PubChem number24199313
-
Scientific contextAuranofin is derivative of gold and has been widely used as an anti-arthritic drug. It inhibits both leukocyte activation pathways at multiple sites and the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin has been shown to inhibit human neutrophil 5-lipoxygenase, thioredoxin reductase (TrxR), IκB kinase (IKK).
-
Bibliography1. Betts W.H., Hurst N.P., Murphy G.A., & Cleland L.G. (1990) Biochem. Pharm. 39(7). 1233–1237. 2. Rudkowski R., Ziegler J.B., Graham G.G., & Champion G.D. (1991) Biochem. Pharm. 41(12): 1921–1929.
-
Release date1-Oct-2014
-
PubMed numberRefer to PubMed
-
Tested applicationsTo be tested
-
Tested reactivityTo be tested
-
Representative figure legendChemical structure of Auranofin (SIH-493), a IKK kinase inhibitor. CAS #: 34031-32-8. Molecular Formula: C20H34AuO9PS. Molecular Weight: 678.5 g/mol. Chemical structure of Auranofin, a IKK kinase inhibitor (SIH-493). CAS # 34031-32-8. Molecular Formula: C20H34AuO9PS.
-
Warning informationNon-hazardous
-
Country of productionCanada
-
Total weight kg0.25
-
Net weight g0.05
-
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
Gene target
-
Gene symbolIKBKE, IKBKB, CHUK, IKBKG
-
Short nameAuranofin, IKK kinase inhibitor
-
Alternative nameAuranofin, IKK phosphorylation catalyst suppressor
-
Gene info
-
Identity
-
Gene
-
Long gene nameinhibitor of nuclear factor kappa B kinase subunit epsilon
-
Synonyms gene name
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2002-12-02
-
Entrez gene record
-
Pubmed identfication
-
Classification
- I kappa B kinases
- MicroRNA protein coding host genes
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinhibitor of nuclear factor kappa B kinase subunit beta
-
Synonyms gene name
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1998-02-11
-
Entrez gene record
-
Pubmed identfication
-
Classification
- I kappa B kinases
- IKK complex
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene namecomponent of inhibitor of nuclear factor kappa B kinase complex
-
Synonyms gene
-
Synonyms gene name
- conserved helix-loop-helix ubiquitous kinase
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1995-03-15
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- I kappa B kinases
- IKK complex
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinhibitor of nuclear factor kappa B kinase regulatory subunit gamma
-
Synonyms gene
-
Synonyms gene name
- incontinentia pigmenti
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
- inhibitor of nuclear factor kappa B kinase subunit gamma
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1998-09-30
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Zinc fingers C2HC-type
- IKK complex
-
VEGA ID
-
Locus Specific Databases
