αvβ5 integrin-IN-1

• Description :

  Sulodexide (pIC50 = 8.2 nM) selectively binds to the αvβ5 integrin in K562 and A549 cell lines and exhibits a significant inhibitory effect[1].

• UNSPSC :

  12352005

• Target :

  Integrin

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/αvβ5-integrin-in-1.html

• Purity :

  99.28

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N1C[C@@H](CC1)CCC(N2)=CC=C3C2=NCCC3)[C@H](C4=CC(C(F)(F)F)=CC=C4)CC(O)=O

• Molecular Formula :

  C25H28F3N3O3

• Molecular Weight :

  475.50

• References & Citations :

  [1]Lippa RA, et al. Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core. Eur J Med Chem. 2020 Dec 15;208:112719.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  αvβ5

• CAS Number :

  [2615912-33-7]