αvβ1 integrin-IN-2

• Description :

  αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of integrins ανβ1 and α5β1 with IC50s of 0.9 nM, and 33 nM, respectively. αvβ1 integrin-IN-2 also inhibits other integrins with, , IC50s of 380 nM (ανβ3), 280 nM (ανβ5), 230 nM (ανβ6), 87 nM (ανβ8), respectively, in SPRA assay[1].

• UNSPSC :

  12352005

• Target :

  Integrin

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/αvβ1-integrin-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(CC(CC1=NN(C)C(OCCC2=CC=C3C(N2)=NCCC3)=C1)C4=CC(C(C)(C)C)=CC=C4OC)O

• Molecular Formula :

  C29H38N4O4

• Molecular Weight :

  506.64

• References & Citations :

  [1]Ruminski PG, et al. Preparation of ((tetrahydronaphthyridinylethoxy) pyrazolyl) butanoic acid as integrin antagonists for the treatment and prevention of diseases. World Intellectual Property Organization, WO2018132268 A1. 2018-07-19.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2234874-68-9]