αvβ1 integrin-IN-2

αvβ1 integrin-IN-2

• CAS Number: 2234874-68-9
• UNSPSC Description: αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of integrins ανβ1 and α5β1 with IC50s of 0.9 nM，and 33 nM，respectively. αvβ1 integrin-IN-2 also inhibits other integrins with ，，IC50s of 380 nM (ανβ3)，280 nM (ανβ5)，230 nM (ανβ6)，87 nM (ανβ8)，respectively，in SPRA assay[1].
• Target Antigen: Integrin
• Type: Reference compound
• Related Pathways: Cytoskeleton
• Applications: COVID-19-immunoregulation
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/αvβ1-integrin-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(CC(CC1=NN(C)C(OCCC2=CC=C3C(N2)=NCCC3)=C1)C4=CC(C(C)(C)C)=CC=C4OC)O
• Molecular Weight: 506.64
• References & Citations: [1]Ruminski PG, et al. Preparation of ((tetrahydronaphthyridinylethoxy)pyrazolyl) butanoic acid as integrin antagonists for the treatment and prevention of diseases. World Intellectual Property Organization, WO2018132268 A1. 2018-07-19.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported