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αvβ1 integrin-IN-2

CAT: 0804-HY-156521Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156521Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of integrins ανβ1 and α5β1 with IC50s of 0.9 nM, and 33 nM, respectively. αvβ1 integrin-IN-2 also inhibits other integrins with, , IC50s of 380 nM (ανβ3), 280 nM (ανβ5), 230 nM (ανβ6), 87 nM (ανβ8), respectively, in SPRA assay[1].
CAS Number
2234874-68-9
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/αvβ1-integrin-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(CC(CC1=NN(C)C(OCCC2=CC=C3C(N2)=NCCC3)=C1)C4=CC(C(C)(C)C)=CC=C4OC)O
Molecular Formula
C29H38N4O4
Molecular Weight
506.64
References & Citations
[1]Ruminski PG, et al. Preparation of ((tetrahydronaphthyridinylethoxy) pyrazolyl) butanoic acid as integrin antagonists for the treatment and prevention of diseases. World Intellectual Property Organization, WO2018132268 A1. 2018-07-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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