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α5β1 integrin agonist-1

CAT: 0804-HY-139702-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139702-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α5β1 integrin agonist-1 is an α5β1 integrin agonist, with an EC50 of 1.5 nM. α5β1 integrin agonist-1 inhabits α4β1 integrin (IC50 = 2.99 μM) in Jurkat/VCAM-1 adhesion assayα5β1 integrin agonist-1 induces concentration-dependent apoptosis and activates the caspase 3/7 pathway in α5β1 integrin-expressing K562 cancer cells. α5β1 integrin agonist-1 can be used for the study of cancer[1].
CAS Number
2756557-83-0
UNSPSC
12352005
Target
Apoptosis; Caspase; Integrin
Type
Reference compound
Related Pathways
Apoptosis; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/α5β1-integrin-agonist-1.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C[C@H]1N(C([C@]1([H])[C@@H](C)OC(CCNC(CN2C(NC(C(F)=C2)=O)=O)=O)=O)=O)C(NC3=C(C=CC=C3)C)=O)=O
Molecular Formula
C24H26FN5O9
Molecular Weight
547.49
References & Citations
[1]Baiula M, et al. Selective Integrin Ligands Promote Cell Internalization of the Antineoplastic Agent Fluorouracil. ACS Pharmacol Transl Sci. 2021 Sep 2;4 (5) :1528-1542.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α4β1; α5β1

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