2-NP

• Description :

  2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H318

• Target :

  HSV; JAK; STAT

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/2-np.html

• Purity :

  99.89

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OC1=CC=CC=C1C2=NC3=NC=CC=C3C=C2

• Molecular Formula :

  C14H10N2O

• Molecular Weight :

  222.25

• Precautions :

  H302, H318

• References & Citations :

  [1]Lynch RA, et, al. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 1;67 (3) :1254-61.|[2]Luo N, et al., Up-regulated Lnc BTU promotes the production of duck plague virus DNA polymerase and inhibits the activation of JAK-STAT pathway to facilitate duck plague virus replication. Poult Sci. 2024 Dec;103 (12) :104238.|[3]Wang Y, et al., A small-molecule enhancer of STAT1 affects herpes simplex keratitis prognosis by mediating plasmacytoid dendritic cells migration through CXCR3/CXCL10. Int Immunopharmacol. 2025 Feb 6;147:113959.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [65182-56-1]