NR2F2-IN-1 (free base)

NR2F2-IN-1 (free base)

• CAS Number: 452087-38-6
• UNSPSC Description: NR2F2-IN-1 (free base) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 (free base) substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nr2f2-in-1-free-base.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: COC(C(OC)=C1)=CC=C1CCNC2=C3C=C(C)SC3=NC=N2
• Molecular Weight: 329.42
• References & Citations: [1]Leiming Wang, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci Adv. 2020 Apr 29;6(18):eaaz8031.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported