NR2F2-IN-1 (free base)

• UNSPSC Description:

  NR2F2-IN-1 (free base) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 (free base) substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nr2f2-in-1-free-base.html

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  COC(C(OC)=C1)=CC=C1CCNC2=C3C=C(C)SC3=NC=N2

• Molecular Weight:

  329.42

• References & Citations:

  [1]Leiming Wang, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci Adv. 2020 Apr 29;6(18):eaaz8031.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  452087-38-6