Aβ42-IN-1 (free base)

Aβ42-IN-1 (free base)

• CAS Number: 2434633-17-5
• UNSPSC Description: Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 μM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease[1].
• Target Antigen: γ-secretase
• Type: Reference compound
• Related Pathways: Neuronal Signaling;Stem Cell/Wnt
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/aβ42-in-1-free-base.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=CC=C5)C=C4)=CC=CN32)C=C1)NCC
• Molecular Weight: 462.54
• References & Citations: [1]Sekioka R, et al. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators. Bioorg Med Chem. 2020 Jan 1;28(1):115132.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported