NR2F2-IN-1

CAT: 0804-HY-156190Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-156190Size:1 Each
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Description
NR2F6 modulator-2 (CIA1) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F6 modulator-2 substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F6 modulator-2 directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation[1].
CAS Number
[1049691-47-5]
UNSPSC
12352005
Target
Orphan Nuclear Receptor; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nr2f6-modulator-2.html
Solubility
10 mM in DMSO
Smiles
COC(C(OC)=C1)=CC=C1CCNC2=C3C=C(C)SC3=NC=N2.Cl
Molecular Formula
C17H20ClN3O2S
Molecular Weight
365.88
References & Citations
[1]Leiming Wang, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci Adv. 2020 Apr 29;6 (18) :eaaz8031.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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