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PR5-LL-CM01

CAT: 0804-HY-109963-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109963-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50= 7.5 μM) . Anti-tumor activies[1].
CAS Number
1005307-86-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pr5-ll-cm01.html
Purity
98.37
Solubility
DMSO : 11.11 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 80°C)
Smiles
CC1=CC=C(NC2=C3C(N(C4=CC=CC=C4)N=C3)=NC(NCCN(C)C)=N2)C=C1C
Molecular Formula
C23H27N7
Molecular Weight
401.51
Precautions
H302, H315, H319
References & Citations
[1]Prabhu L, et al. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. Oncotarget. 2017;8 (25) :39963-39977.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5

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