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LL-K12-18

CAT: 0804-HY-163944-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163944-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the CDK12-DDB1 complex, stabilizing the CDK12-DDB1 complex and promoting the degradation of cyclin K (EC50=0.37 nM) . LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research[1].
UNSPSC
12352005
Target
CDK; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ll-k12-18.html
Purity
98.42
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCN1C=NC2=C1N=C(N(CC3)CCN3C(CN(CC)CC)=O)N=C2NCC4=NC5=CC(Cl)=C(C=C5N4)Cl
Molecular Formula
C25H32Cl2N10O
Molecular Weight
559.49
References & Citations
[1]Zemin Zhang, et al. "Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex." Nature Communications 15.1 (2024) : 6477.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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