LL-K12-18

• Description:

  LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the CDK12-DDB1 complex, stabilizing the CDK12-DDB1 complex and promoting the degradation of cyclin K (EC50=0.37 nM) . LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research[1].

• UNSPSC:

  12352005

• Target:

  CDK; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ll-k12-18.html

• Purity:

  98.42

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CCN1C=NC2=C1N=C(N(CC3)CCN3C(CN(CC)CC)=O)N=C2NCC4=NC5=CC(Cl)=C(C=C5N4)Cl

• Molecular Formula:

  C25H32Cl2N10O

• Molecular Weight:

  559.49

• References & Citations:

  [1]Zemin Zhang, et al. "Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex." Nature Communications 15.1 (2024) : 6477.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported