Products for Research Use Only
RegisterLogin

LL-Z1640-4

CAT: 0804-HY-120349Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-120349Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4[1][2].
CAS Number
66018-41-5
UNSPSC
12352005
Target
Apoptosis; JNK; p38 MAPK; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ll-z1640-4.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C1OC(C/C=C/C(C(C(C/C=C/C2=C1C(O)=CC(OC)=C2)O)O)O)C
Molecular Formula
C19H24O7
Molecular Weight
364.39
References & Citations
[1]Ellestad George A, et al. New zearalenone related macrolides and isocoumarins from an unidentified fungus. The Journal of Organic Chemistry, 1978,43 (12) :2339–2343.|[2]Li Y, Zuo H, Wang H, Hu A. Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling. Biomed Pharmacother. 2019 Aug;116:108749.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P5729LL-25
HY-118132LL-Z1220
HY-P4748LL-21
HY-136828LL-BM123α
HY-115843LL-D05139β
HY-P10262LL-37-Cys
HY-156084-01LL-K9-3
HY-163944-01LL-K12-18
HY-P4128LL-37 SKE
HY-109963-01PR5-LL-CM01

Alternative Products

CatalogName
L039-5MGLL Z1640-4
441619-01Antibiotic LL Z1640-4
L038-5MGLL Z1640-2
MBS651283-01Antibiotic LL Z1640-4 (Zeaenol)
GTR19229206-01Antibiotic LL-Z1640-6
574446Antibiotic LL Z1640-2
441618-01Antibiotic LL Z1640-2 discontinued. See A2297-23
A2297-23-01Antibiotic LL Z1640-2 (Antibiotic C292, Antibiotic L 783278)
MBS5757404LL-Z 1640-4
sc-100323CRMP-4 (LL-5)

Popular Products