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Bicuculline methiodide

CAT: 0804-HY-103474-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103474-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bicuculline methiodide ((-) -Bicuculline methiodide) is a potent GABAA blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].
CAS Number
40709-69-1
Product Name Alternative
(-) -Bicuculline methiodide
UNSPSC
12352005
Hazard Statement
H301, H311, H330, H400
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bicuculline-methiodide.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 150 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[N+]1([C@](C2=C(CC1)C=C3C(OCO3)=C2)([H])[C@@]4([H])C5=C(C6=C(OCO6)C=C5)C(O4)=O)C.[I-]
Molecular Formula
C21H20INO6
Molecular Weight
509.29
Precautions
H301, H311, H330, H400
References & Citations
[1]Johnson SW, et al. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neurosci Lett. 1997 Aug 1;231 (1) :13-6. |[2]Yang Y, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature, 2018, 554 (7692) : 317-322. |[3]Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107 (3) :1064-9. |[4]Sperber EF, et al. Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain Res. 1987 Dec 15;465 (1-2) :243-50.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
BioRxiv. 2024 November 26.|Brain Behav Immun. 2019 Nov:82:45-62.|Cell Rep. 2025 May 14;44 (5) :115712.

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