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(+) -Bicuculline (methochloride)

CAT: 0804-HY-100783ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100783ASize:1 Each
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Description
(+) -Bicuculline methobromide is a potent GABAA blocker. (+) -Bicuculline methobromide alters membrane properties and firing pattern. (+) -Bicuculline methobromide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. (+) -Bicuculline methobromide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].
CAS Number
53552-05-9
UNSPSC
12352005
Hazard Statement
H300-H311-H331-H400
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/minus-bicuculline-methochloride.html
Solubility
10 mM in DMSO
Smiles
C[N+]1([C@](C2=C(CC1)C=C3C(OCO3)=C2)([H])[C@@]4([H])C5=C(C6=C(OCO6)C=C5)C(O4)=O)C.[Cl-]
Molecular Formula
C21H20ClNO6
Molecular Weight
417.84
Precautions
P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P361+P364-P391-P403+P233-P405-P501
References & Citations
[1]Johnson SW, et al. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neurosci Lett. 1997 Aug 1;231 (1) :13-6. |[2]Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107 (3) :1064-9.|[3]Yang Y, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature, 2018, 554 (7692) : 317-322. |[4]Sperber EF, et al. Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain Res. 1987 Dec 15;465 (1-2) :243-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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