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Bicuculline (methobromide)

CAT: 0804-HY-100783BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100783BSize:1 Each
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Description
Bicuculline methobromide is a selective GABAA Receptor antagonist with an IC50 value of 3 μM. Bicuculline methobromide induces clonic tonic convulsions in mammals and can also be used to block Ca2+ activated potassium channels. Bicuculline methobromide can be used in studies of epilepsy and other related psychiatric disorders[1][2].
CAS Number
66016-70-4
Product Name Alternative
(+) -Bicuculline (methobromide)
UNSPSC
12352005
Hazard Statement
H300-H311+H331-H410
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bicuculline-methobromide.html
Solubility
10 mM in DMSO
Smiles
C[N+]1([C@](C2=C(CC1)C=C3C(OCO3)=C2)([H])[C@@]4([H])C5=C(C6=C(OCO6)C=C5)C(O4)=O)C.[Br-]
Molecular Formula
C21H20BrNO6
Molecular Weight
462.29
Precautions
P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P361+P364-P391-P403+P233-P405-P501
References & Citations
[1]Y Yajima, et al. Effects of differential modulation of mu-, delta- and kappa-opioid systems on bicuculline-induced convulsions in the mouse. Brain Res. 2000 Apr 17;862 (1-2) :120-6.|[2]W A Turski, et al. Excitatory amino acid antagonists protect mice against seizures induced by bicuculline. Brain Res. 1990 Apr 23;514 (1) :131-4.|[3]Huang SH, et al. Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA (A) receptors. Eur J Pharmacol. 2003;464 (1) :1-8. |[4]Khawaled R, et al. Bicuculline block of small-conductance calcium-activated potassium channels. Pflugers Arch. 1999 Aug;438 (3) :314-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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