8-Bromoadenine

• Description:

  8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium[1][2].

• Product Name Alternative:

  8-Bromo-9H-purin-6-amine

• UNSPSC:

  12352200

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Biochemical Assay Reagents; DNA/RNA Synthesis

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Cell Cycle/DNA Damage; Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/8-bromoadenine.html

• Purity:

  98.92

• Solubility:

  0.1 M NaOH : 0.2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  BrC1=NC2=C(N1)C(N)=NC=N2

• Molecular Formula:

  C5H4BrN5

• Molecular Weight:

  214.03

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Tkalich A V, et al. Effect of 8-bromoadenine on DNA repair[J]. Tsitologiia, 1980, 22 (8) : 994-997.|[2]Radioactively marked nucleic acid units. German Democratic Republic, DD106383 A1 1974-06-12.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [6974-78-3]