Products for Research Use Only
RegisterLogin

JNJ-28312141

CAT: 0804-HY-13496-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13496-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JNJ-28312141 is an inhibitor for colony-stimulating factor-1 receptor (CSF-1R or FMS), with an IC50 of 0.69 nM. JNJ-28312141 inhibits proliferation of BDBM, MV-4-11, M-o7e, TF-1 with an IC50s of 2.6, 21, 41 and 150 nM, respectively. JNJ-28312141 exhibits anti-inflammatory activity in mouse arthritis model[1].
CAS Number
885692-52-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
C-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnj-28312141.html
Smiles
O=C(C1=NC(C#N)=CN1)NC2=C(C3=CCCCC3)C=C(C4CCN(C(CN(C)C)=O)CC4)C=C2
Molecular Formula
C26H32N6O2
Molecular Weight
460.57
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Illig CR, et al., Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2- (1-cyclohexen-1-yl) -4-[1-[ (dimethylamino) acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141) . J Med Chem. 2011 Nov 24;54 (22) :7860-83.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-172194JNJ-3738
HY-P991172JNJ-70218902
HY-113751-01JNJ-39393406
HY-132895JNJ-67569762
HY-118424-01JNJ-55511118
HY-110132-01JNJ-27141491
HY-19917-01JNJ-39220675
HY-123531JNJ 10329670
HY-148240-01JNJ-65355394
HY-111066-01JNJ-37822681

Alternative Products

CatalogName
MBS3606405-01JNJ-28312141
MBS131127-01JNJ 28312141
A12687-100JNJ-28312141 100mg
A12687-10JNJ-28312141 10mg
M16981JNJ-28312141 hydrochloride
A12687-50JNJ-28312141 50mg
A12687-5JNJ-28312141 5mg
A12687-25JNJ-28312141 25mg
MBS131356JNJ-63533054 (JNJ63533054; JNJ 63533054)
BA6861-10JNJ-42253432

Popular Products