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JNJ 10329670

CAT: 0804-HY-123531Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123531Size:1 Each
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Description
JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation[1].
CAS Number
400797-24-2
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnj-10329670.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=CC=C(C=C1)C2=NN(C3=C2CN(CC3)S(=O)(C)=O)CCCN4CCC(CC4)N5C6=CC(Cl)=CC=C6N(C5=O)C
Molecular Formula
C30H34ClF3N6O3S
Molecular Weight
651.14
References & Citations
[1]Thurmond RL, et, al. Identification of a potent and selective noncovalent cathepsin S inhibitor. J Pharmacol Exp Ther. 2004 Jan;308 (1) :268-76.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin S

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