α-Hydroxyglutaric acid (disodium)
CAT:
804-HY-113038A-03
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
α-Hydroxyglutaric acid (disodium)
- CAS Number: 40951-21-1
- UNSPSC Description: α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].
- Target Antigen: Endogenous Metabolite; Histone Demethylase
- Type: Natural Products
- Related Pathways: Epigenetics;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/α-hydroxyglutaric-acid-disodium.html
- Purity: 98.0
- Solubility: H2O : 125 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(O[Na])C(O)CCC(O[Na])=O
- Molecular Weight: 192.08
- References & Citations: [1]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported