4β-Hydroxywithanolide E

• UNSPSC Description:

  4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression[1].

• Target Antigen:

  PPAR

• Type:

  Natural Products

• Related Pathways:

  Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/4β-hydroxywithanolide-e.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]1(C2=O)[C@@]3([C@H](C=C2)O)[C@](C[C@]([C@@]4(CC[C@](O)5[C@@](O)([C@@](OC6=O)([H])CC(C)=C6C)C)O)([H])[C@]1([H])CC[C@@]45C)([H])O3

• Molecular Weight:

  502.60

• References & Citations:

  [1]Momochika Kumagai, et al. 4β-Hydroxywithanolide E and withanolide E from Physalis peruviana L. inhibit adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. J Nat Med. 2021 Jan;75(1):232-239.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  54334-04-2