(E) -Methyl 4-coumarate

• Description:

  (E) -Methyl 4-coumarate (Methyl 4-hydroxycinnamate) is a phenolic compound and derivative of Cinnamic acid (HY-N0610A) . (E) -Methyl 4-coumarate can be found in several plants, such as the leaves of Allium cepa and Morinda citrifolia L. (E) -Methyl 4-coumarate, when combined with Carnosic acid (HY-N0644), induces Apoptosis. (E) -Methyl 4-coumarate inhibits GSK3β activity and modulates inflammatory cytokine levels (increasing IL-10 and decreasing IL-4) . (E) -Methyl 4-coumarate combined with Carnosic acid exhibits anticancer effects against acute myeloid leukemia. (E) -Methyl 4-coumarate ameliorates Plasmodium berghei NK65 infection[1][2].

• Product Name Alternative:

  Methyl trans-p-coumarate

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; GSK-3; Interleukin Related; Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Immunology/Inflammation; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/e-methyl-4-coumarate.html

• Purity:

  99.87

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(OC)/C=C/C1=CC=C(O)C=C1

• Molecular Formula:

  C10H10O3

• Molecular Weight:

  178.19

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Trachtenberg A, et al. Synergistic Cytotoxicity of Methyl 4-Hydroxycinnamate and Carnosic Acid to Acute Myeloid Leukemia Cells via Calcium-Dependent Apoptosis Induction. Front Pharmacol. 2019 May 9;10:507.|[2]SUDI S, et al. A DERIVATIVE OF CINNAMIC ACID, METHYL-4-HYDROXYCINNAMATE MODULATES INFLAMMATORY CYTOKINE LEVELS IN MALARIA-INFECTED MICE THROUGH INHIBITION OF GSK3. Malaysian Applied Biology, 2018, 47 (3) : 153-157.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  GSK-3β; IL-10; IL-4

• CAS Number:

  19367-38-5