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(E) -Methyl 4-coumarate

CAT: 0804-HY-N2492-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-N2492-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E) -Methyl 4-coumarate (Methyl 4-hydroxycinnamate) is a phenolic compound and derivative of Cinnamic acid. (E) -Methyl 4-coumarate can be found in several plants, such as the leaves of Allium cepa and Morinda citrifolia L. (E) -Methyl 4-coumarate, when combined with Carnosic acid (HY-N0644), induces Apoptosis. (E) -Methyl 4-coumarate inhibits GSK3β activity and modulates inflammatory cytokine levels (increasing IL-10 and decreasing IL-4). (E) -Methyl 4-coumarate combined with Carnosic acid exhibits anticancer effects against acute myeloid leukemia. (E) -Methyl 4-coumarate ameliorates Plasmodium berghei NK65 infection[1][2].
CAS Number
19367-38-5
Product Name Alternative
Methyl trans-p-coumarate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; GSK-3; Interleukin Related; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/e-methyl-4-coumarate.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC)/C=C/C1=CC=C(O)C=C1
Molecular Formula
C10H10O3
Molecular Weight
178.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Trachtenberg A, et al. Synergistic Cytotoxicity of Methyl 4-Hydroxycinnamate and Carnosic Acid to Acute Myeloid Leukemia Cells via Calcium-Dependent Apoptosis Induction. Front Pharmacol. 2019 May 9;10:507.|[2]SUDI S, et al. A DERIVATIVE OF CINNAMIC ACID, METHYL-4-HYDROXYCINNAMATE MODULATES INFLAMMATORY CYTOKINE LEVELS IN MALARIA-INFECTED MICE THROUGH INHIBITION OF GSK3. Malaysian Applied Biology, 2018, 47 (3) : 153-157.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GSK-3β; IL-10; IL-4

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