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AEEA-AEEA

CAT: 0804-HY-W125504-02Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W125504-02Size:10 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
CAS Number
1143516-05-5
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aeea-aeea.html
Purity
99.12
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)COCCOCCNC(COCCOCCN)=O
Molecular Formula
C12H24N2O7
Molecular Weight
308.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker

Chemical Information

17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic acid
CAS Number1143516-05-5
PubChem CID51340918
IUPAC Name2-[2-[2-[[2-[2-(2-aminoethoxy)ethoxy]acetyl]amino]ethoxy]ethoxy]acetic acid
Molecular FormulaC12H24N2O7
Molecular Weight308.33
XLogP-4.6
Topological Polar Surface Area129
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count15
Heavy Atom Count21
Formal Charge0
Complexity276
SMILES
C(COCCOCC(=O)NCCOCCOCC(=O)O)N
InChI
InChI=1S/C12H24N2O7/c13-1-3-18-5-7-20-9-11(15)14-2-4-19-6-8-21-10-12(16)17/h1-10,13H2,(H,14,15)(H,16,17)
InChIKey
YQZVQKYXWPIKIX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic acid
CAS: 1143516-05-5
CID: 51340918
Formula: C12H24N2O7
MW: 308.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight308.33
XLogP3-4.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count15
Exact Mass308.15835111
Monoisotopic Mass308.15835111
Topological Polar Surface Area129 Ų
Heavy Atom Count21
Formal Charge0
Complexity276
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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