6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) (TFA)

• UNSPSC Description:

  6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA (6-FAM-AEEAC-SHK TFA) is a peptide neurotoxin conjugated with a fluorescent marker. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can block voltage-gated potassium channels (kv1.1 and kv1.2) to prolong the duration of action potentials, thereby affecting the conduction of neural signals. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can be used in neuroscience research[1].

• Target Antigen:

  Biochemical Assay Reagents; Potassium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel;Others

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/6-fam-aeeac-stichodactyla-helianthus-neurotoxin-shk-tfa.html

• Purity:

  95.21

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  OC([C@H](CSSC[C@@H]1NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC(COCCOCCNC(C2=CC(C3(C4=C(OC5=C3C=CC(O)=C5)C=C(O)C=C4)O6)=C(C=C2)C6=O)=O)=O)=O)=O)NC([C@H]([C@H](O)C)NC(CNC([C@H](CSSC[C@@H]7NC([C@H](CCC(N)=O)NC([C@H](CC8=CC=CC=C8)NC([C@H](C)NC([C@H]([C@H](O)C)N9)=O)=O)=O)=O)NC([C@H]([C@H](O)C)NC(C(CCCCN)NC(C(CCCNC(N)=N)NC([C@H](CSSC[C@@H](C9=O)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H]%10N(C([C@H]([C@@H](C)CC)NC([C@H]([C@H](O)C)NC([C@H](CC(O)=O)NC([C@H]([C@@H](C)CC)NC1=O)=O)=O)=O)=O)CCC%10)=O)=O)=O)=O)NC([C@H](CC%11=CC=CC=C%11)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CC%12=CC=C(C=C%12)O)NC([C@H](CCCCN)NC([C@H](CCSC)NC([C@H](CO)NC([C@H](CC%13=CNC=N%13)NC([C@H](CCCCN)NC7=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(C(F)(F)F)O.[x]

• Molecular Weight:

  4558.23 (free acid)

• References & Citations:

  [1]Devaux, et al. "Tight junctions potentiate the insulative properties of small CNS myelinated axons." The Journal of cell biology 183.5 (2008): 909-921.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported