AEEA-AEEA

• Description :

  AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Linker; PROTAC Linkers

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/aeea-aeea.html

• Purity :

  99.12

• Solubility :

  DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(O)COCCOCCNC(COCCOCCN)=O

• Molecular Formula :

  C12H24N2O7

• Molecular Weight :

  308.33

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker

• CAS Number :

  [1143516-05-5]