Acyclovir (Standard)

• UNSPSC Description:

  Acyclovir (Standard) is the analytical standard of Acyclovir. This product is intended for research and analytical applications. Acyclovir (Aciclovir) is a potent, orally active antiviral agent. Acyclovir has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir induces cell cycle perturbation and apoptosis. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[1][2][3][4].

• Target Antigen:

  Antibiotic; Apoptosis; Bacterial; HSV

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection;Apoptosis

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/acyclovir-standard.html

• Smiles:

  O=C1NC(N)=NC2=C1N=CN2COCCO

• Molecular Weight:

  225.20

• References & Citations:

  [1]Benedetti S, et, al. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells, and enhances chemotherapeutic drug cytotoxicity. Life Sci. 2018 Dec 15;215:80-85.|[2]Suzuki M, et, al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61.|[3]Li Z, et, al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep;10(5):251-7.|[4]Lönnqvist B, et, al. Oral acyclovir as prophylaxis for bacterial infections during induction therapy for acute leukaemia in adults. The Leukemia Group of Middle Sweden. Support Care Cancer. 1993 May;1(3):139-44.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  59277-89-3