Acyclovir monophosphate

• Description:

  Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity[1][2].

• UNSPSC:

  12352005

• Target:

  Antibiotic; HSV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/acyclovir-monophosphate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N=C(NC2=C1N=CN2COCCOP(O)(O)=O)N

• Molecular Formula:

  C8H12N5O6P

• Molecular Weight:

  305.18

• References & Citations:

  [1]Yao J, et al. Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate. J Control Release. 2013 Sep 28;170 (3) :414-20.|[2]Elion GB, et al. Mechanism of action and selectivity of acyclovir. Am J Med. 1982 Jul 20;73 (1A) :7-13.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [66341-16-0]