Acyclovir triphosphate (sodium)

• Description :

  Acyclovir triphosphate (Synonyms: AcycloGTP) sodium is a Acyclovir (HY-17422) derivative that competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP) . Acyclovir triphosphate sodium is an inhibitor of HIV-1 reverse transcriptase. Acyclovir triphosphate sodium causes termination of viral DNA synthesis[1].

• Product Name Alternative :

  AcycloGTP (sodium)

• UNSPSC :

  12352200

• Target :

  DNA/RNA Synthesis; HIV; Nucleoside Antimetabolite/Analog; Reverse Transcriptase

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/acyclovir-triphosphate-sodium.html

• Concentration :

  100 mM * 500 μL in water

• Purity :

  99.71

• Smiles :

  O=P(OP(OP(OCCOCN1C(N=C(N)NC2=O)=C2N=C1)(O)=O)(O)=O)(O)O.[x].[Na]

• Molecular Formula :

  C8H14N5O12P3.xNa

• References & Citations :

  [1]Hirsch MS, et al. Drug therapy: antiviral agents (second of two parts) . N Engl J Med. 1980 Apr 24;302 (17) :949-53. |[2]McMahon MA, et al. Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses. J Virol. 2011 May;85 (9) :4618-22.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported

• CAS Number :

  [221119-43-3]