Acyclovir triphosphate (sodium)

• Description:

  Acyclovir triphosphate (Synonyms: AcycloGTP) sodium is a Acyclovir (HY-17422) derivative that competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP) . Acyclovir triphosphate sodium is an inhibitor of HIV-1 reverse transcriptase. Acyclovir triphosphate sodium causes termination of viral DNA synthesis[1].

• Product Name Alternative:

  AcycloGTP (sodium)

• UNSPSC:

  12352200

• Target:

  DNA/RNA Synthesis; HIV; Nucleoside Antimetabolite/Analog; Reverse Transcriptase

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/acyclovir-triphosphate-sodium.html

• Concentration:

  100 mM * 500 μL in water

• Purity:

  99.71

• Smiles:

  O=P (OP (OP (OCCOCN1C (N=C (N) NC2=O) =C2N=C1) (O) =O) (O) =O) (O) O.[x].[Na]

• Molecular Formula:

  C8H14N5O12P3.xNa

• References & Citations:

  [1]Hirsch MS, et al. Drug therapy: antiviral agents (second of two parts) . N Engl J Med. 1980 Apr 24;302 (17) :949-53. |[2]McMahon MA, et al. Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses. J Virol. 2011 May;85 (9) :4618-22.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  221119-43-3