Acyclovir (hydrochloride)

• Description:

  Acyclovir (Aciclovir) hydrochloride is a potent, orally active antiviral agent. Acyclovir hydrochloride has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir hydrochloride induces cell cycle perturbation and apoptosis. Acyclovir hydrochloride prevents bacterial infections during induction therapy for acute leukaemia[1][2][3][4].

• Product Name Alternative:

  Aciclovir (hydrochloride) ; Acycloguanosine (hydrochloride)

• UNSPSC:

  12352005

• Target:

  Antibiotic; Apoptosis; Bacterial; HSV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Apoptosis

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/acyclovir-hydrochloride.html

• Smiles:

  O=C1N=C(NC2=C1N=CN2COCCO)N.Cl

• Molecular Formula:

  C8H12ClN5O3

• Molecular Weight:

  261.67

• References & Citations:

  [1]Benedetti S, et, al. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells, and enhances chemotherapeutic drug cytotoxicity. Life Sci. 2018 Dec 15;215:80-85.|[2]Suzuki M, et, al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72 (2) :157-61.|[3]Li Z, et, al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep;10 (5) :251-7.|[4]Lönnqvist B, et, al. Oral acyclovir as prophylaxis for bacterial infections during induction therapy for acute leukaemia in adults. The Leukemia Group of Middle Sweden. Support Care Cancer. 1993 May;1 (3) :139-44.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 4

• CAS Number:

  [1628039-62-2]