AD 01

• Description :

  AD 01, a 24 amino acid peptide of FKBPL (FK506-binding protein like), possesses potent anti-angiogenic activity. AD 01 bind to the CD44 receptor and inhibit tumour cell migration in a CD44 dependant manner[1][2].

• UNSPSC :

  12352209

• Target :

  Transmembrane Glycoprotein

• Type :

  Peptides

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ad-01.html

• Purity :

  99.98

• Solubility :

  H2O : ≥ 100 mg/mL

• Smiles :

  O=C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N3[C@@H](CCC3)C(N[C@@H](C)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]4N(CCC4)C([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]5N(CCC5)C([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H]([C@@H](C)CC)NC([C@@H](N)CCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C115H187N33O42

• Molecular Weight :

  2703.94

• References & Citations :

  [1]Andrea Valentine, et al. FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism. Clin Cancer Res. 2011 Mar 1;17 (5) :1044-56.|[2]Anita Yakkundi, et al. The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway. PLoS One. 2013;8 (2) :e55075.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [959961-23-0]