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AD-2646

CAT: 0804-HY-124134Size: 1 EachDry Ice: NoHazardous: No
CAT#: HY-124134Size: 1 Each
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC50: 40 μM) . AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism[1][2].
CAS Number
[366487-89-0]
Product Name Alternative
LCL102
UNSPSC
12352005
Target
Caspase; Ceramidase; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ad-2646.html
Smiles
O[C@H](C1=CC=C([N+]([O-])=O)C=C1)[C@H](NCCCCCCCCCCCCCC)CO
Molecular Formula
C23H40N2O4
Molecular Weight
408.57
References & Citations
[1]Granot T, et al. Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs. Leukemia. 2006 Mar;20 (3) :392-9.|[2]Fumiaki Tanaka, et al. In Vivo and In Vitro Inhibition of Human Cancer Cell Growth Using Adenoviral Vector Expressing FHIT Gene: Mechanism Analysis Using Microarray. Volume 7, Issue 5, Supplement S418-S419. May 2003.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 8; Caspase 9

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