AD-2646

AD-2646

• CAS Number: 366487-89-0
• UNSPSC Description: AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC50: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism[1][2].
• Target Antigen: Caspase; Ceramidase; PARP
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ad-2646.html
• Smiles: O[C@H](C1=CC=C([N+]([O-])=O)C=C1)[C@H](NCCCCCCCCCCCCCC)CO
• Molecular Weight: 408.57
• References & Citations: [1]Granot T, et al. Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs. Leukemia. 2006 Mar;20(3):392-9.|[2]Fumiaki Tanaka, et al. In Vivo and In Vitro Inhibition of Human Cancer Cell Growth Using Adenoviral Vector Expressing FHIT Gene: Mechanism Analysis Using Microarray. Volume 7, Issue 5, Supplement S418-S419. May 2003.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported