Ad-JQ1

• Description:

  Ad-JQ1 (Compound 16) is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-176390), which recruits E3 ligases. Ad-JQ1 can be used for synthesis of PROTAC β-NF-JQ1 (HY-130256) [1].

• UNSPSC:

  12352005

• Target:

  Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates

• Related Pathways:

  Epigenetics; PROTAC

• Field of Research:

  Cancer

• Smiles:

  O=C(NCCOCCOCCNC(C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1)=O)CC5(C[C@@H](C6)C7)C[C@@H]7C[C@@H]6C5

• Molecular Formula:

  C37H47ClN6O4S

• Molecular Weight:

  707.32

• References & Citations:

  [1]Shoda T, et al. Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety. Pharmaceuticals (Basel) . 2020 Feb 25;13 (3) :34.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BRD4

• CAS Number:

  [2497485-14-8]