HMN-176

CAT: 0804-HY-13647-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13647-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1), without significant effect on tubulin polymerization.
CAS Number
[173529-10-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Mitosis; Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/HMN-176.html
Purity
99.00
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2/C=C/C3=CC=N(C=C3)=O)=O
Molecular Formula
C20H18N2O4S
Molecular Weight
382.43
Precautions
H302, H315, H319, H335
References & Citations
[1]DiMaio MA, et al. The small organic compound HMN-176 delays satisfaction of the spindle assembly checkpoint by inhibiting centrosome-dependent microtubule nucleation. Mol Cancer Ther. 2009 Mar;8 (3) :592-601.|[2]Medina-Gundrum L, et al. Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression. Invest New Drugs. 2005 Jan;23 (1) :3-9.|[3]Takagi M, et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest New Drugs. 2003 Nov;21 (4) :387-99.|[4]Tanaka H, et al. HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res. 2003 Oct 15;63 (20) :6942-7.|[5]Garland LL, et al. A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. Clin Cancer Res. 2006 Sep 1;12 (17) :5182-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
BUP07089-01HMN-176
A16327-1HMN-176 1mg
A16327-10HMN-176 10mg
A16327-500HMN-176 500mg
A16327-5HMN-176 5mg
A16327-25HMN-176 25mg
A16327-2HMN-176 2mg
A16327-50HMN-176 50mg
A16327-100HMN-176 100mg
A16327-10mM-DHMN-176 10mM * 1mL in DMSO

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