HMN-214

CAT: 0804-HY-12045-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12045-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
HMN-214, an orally bioavailable proagent of HMN-176, is an inhibitor of polo-like kinase-1 (plk1), with antitumor activity.
CAS Number
[173529-46-9]
Product Name Alternative
IVX-214
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/HMN-214.html
Purity
99.94
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
CC(N(S(=O)(C1=CC=C(OC)C=C1)=O)C2=CC=CC=C2/C=C/C3=CC=[N+]([O-])C=C3)=O
Molecular Formula
C22H20N2O5S
Molecular Weight
424.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Takagi M, et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest New Drugs. 2003 Nov;21 (4) :387-99.|[2]Garland LL, et al. A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. Clin Cancer Res. 2006 Sep 1;12 (17) :5182-9.|[3]Tanaka H, et al. HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res. 2003 Oct 15;63 (20) :6942-7.|[4]Christensen MD, et al. Kinome-level screening identifies inhibition of polo-like kinase-1 (PLK1) as a target for enhancing non-viral transgene expression. J Control Release. 2015 Apr 28;204:20-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PLK1

Related Products

CatalogName
HY-13647-01HMN-176
HY-103001-01HMN-154
HY-172537Indolimine-214
HY-12501A-01ITI-214
HY-164455AJI-214
HY-158116-01VVD-214
HY-P5489-01IGRP (206-214)
HY-W999635CRBN ligand-214
HY-158387Anticancer agent 214
HY-P3813-01Tyrosinase (206-214), human

Alternative Products

CatalogName
abx186468Hmn-214
451949-01HMN 214
A10452-500HMN-214 500mg
A10452-1HMN-214 1mg
A10452-5HMN-214 5mg
A10452-2HMN-214 2mg
A10452-25HMN-214 25mg
A10452-50HMN-214 50mg
A10452-10HMN-214 10mg
A10452-100HMN-214 100mg

Popular Products