BBT-176

• Description:

  BBT-176 is an orally effective EGFR inhibitor. BBT-176 has inhibitory activity against multiple EGFR C797S mutant cell lines. BBT-176 is commonly used in cancer research[1].

• UNSPSC:

  12352100

• Target:

  EGFR

• Related Pathways:

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  O=S(NC1=C(NC2=NC(NC3=CC=C(N4CCC(CC4)N5CCN(CC5)C)C=C3OC)=NC=C2Cl)C=CC=C1)(C)=O

• Molecular Formula:

  C28H37ClN8O3S

• Molecular Weight:

  601.16

• References & Citations:

  [1]Lim SM, et al. BBT-176, a Novel Fourth-Generation Tyrosine Kinase Inhibitor for Osimertinib-Resistant EGFR Mutations in Non-Small Cell Lung Cancer. Clin Cancer Res. 2023 Aug 15;29 (16) :3004-3016.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2254805-44-0]