TGF beta Receptor II Recombinant Rabbit Monoclonal Antibody [JE59-90]

TGF beta Receptor II Recombinant Rabbit Monoclonal Antibody [JE59-90]

• Description: Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene. It is a tumor suppressor gene. This gene encodes a member of the serine/threonine protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler–Weber–Rendu syndrome, and the development of various types of tumors. At least 73 disease-causing mutations in this gene have been discovered. Alternatively spliced transcript variants encoding different isoforms have been characterized.
• Product Name Alternative: AAT3 antibody FAA3 antibody LDS1B antibody LDS2 antibody LDS2B antibody MFS2 antibody RIIC antibody TAAD2 antibody TbetaR II antibody TbetaR-II antibody TGF beta receptor type 2 antibody TGF beta receptor type II antibody TGF beta receptor type IIB antibody TGF beta type II receptor antibody TGF-beta receptor type II antibody TGF-beta receptor type-2 antibody TGF-beta type II receptor antibody TGF-beta-R2 antibody TGFB R2 antibody TGFbeta - RII antibody TGFbeta RII antibody Tgfbr2 antibody TGFR-2 antibody TGFR2_HUMAN antibody Transforming growth factor beta receptor II antibody Transforming growth factor beta receptor type II antibody Transforming growth factor beta receptor type IIC antibody Transforming growth factor, beta receptor II (70/80kDa) antibody transforming growth factor, beta receptor II alpha antibody transforming growth factor, beta receptor II beta antibody transforming growth factor, beta receptor II delta antibody transforming growth factor, beta receptor II epsilon antibody transforming growth factor, beta receptor II gamma antibody Transforming growth factor-beta receptor type II antibody
• Abbreviation: TGFBR2
• CAS Number: 9000-83-3
• Swiss Prot: P37173 Human, P38438 Rat
• Cellular Locus: Cell membrane, Membrane raft; Secreted.
• Host: Rabbit
• Species Reactivity: Human, Rat
• Immunogen: Recombinant protein within Human TGF beta Receptor II aa 1-166 / 567.
• Isotype: IgG
• Clone: JE59-90
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB
• Positive Control: A549 cell lysate, rat lung tissue lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 65 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes