Retinoic Acid Receptor alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody [PSH08-74]

Retinoic Acid Receptor alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody [PSH08-74]

• Description: The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a ligand-activated transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid, retinoid active derivatives of Vitamin A. They are typically found within the nucleus. There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma, encoded by the RARA, RARB, RARG genes, respectively. Within each RAR subtype there are various isoforms differing in their N-terminal region A. Multiple splice variants have been identified in human RARs: four for RARA, five for RARB, and two for RARG. As with other type II nuclear receptors, RAR heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements known as retinoic acid response elements (RAREs) complexed with corepressor protein. Binding of agonist ligands to RAR results in dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein. In addition, the expression of RAR genes is under epigenetic regulation by promoter methylation. Both the length and magnitude of the retinoid response is dependent of the degradation of RARs and RXRs through the ubiquitin-proteasome. This degradation can lead to elongation of the DNA transcription through disruption of the initiation complex or to end the response to facilitate further transcriptional programs. RAR receptors are also known to exhibit many retinoid-independent effects as they bind to and regulate other nuclear receptor pathways, such as the estrogen receptor.
• Product Name Alternative: NR1B1 antibody Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody Nuclear receptor subfamily 1 group B member 1 antibody Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody RAR alpha antibody RAR antibody RAR-alpha antibody rara antibody RARA_HUMAN antibody RARalpha antibody RARalpha1 antibody Retinoic acid nuclear receptor alpha variant 1 antibody Retinoic acid nuclear receptor alpha variant 2 antibody Retinoic acid receptor alpha antibody Retinoic acid receptor alpha polypeptide antibody HAP antibody HBV-activated protein antibody NR1B2 antibody Nuclear receptor subfamily 1 group B member 2 antibody RAR B antibody RAR beta antibody RAR epsilon antibody RAR-beta antibody RAR-epsilon antibody RARB antibody RARB_HUMAN antibody Retinoic acid receptor beta 2 antibody Retinoic acid receptor beta 4 antibody Retinoic acid receptor beta 5 antibody Retinoic acid receptor beta antibody Retinoic acid receptor beta polypeptide antibody RRB2 antibody
• Abbreviation: Retinoic acid receptor alpha RAR-alpha Nuclear receptor subfamily 1 group B member 1 RARA NR1B1 Retinoic acid receptor beta RAR-beta HBV-activated protein Nuclear receptor subfamily 1 group B member 2 RAR-epsilon RARB HAP NR1B2 Retinoic acid receptor gamma RAR-gamma Nuclear receptor subfamily 1 group B member 3 RARG NR1B3
• CAS Number: 9000-83-3
• Swiss Prot: P10276 Human, P10826 Human, P13631 Human, P11416 Mouse, P22605 Mouse, P18911 Mouse,
• Cellular Locus: Nucleus, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within human RARG aa 155-454.
• Isotype: IgG
• Clone: PSH08-74
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB
• Positive Control: SK-Br-3 cell lysate, T-47D cell lysate, A375 cell lysate, HeLa cell lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:5,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 50 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes