Products for Research Use Only
RegisterLogin

HVEGF-IN-1

CAT: 0804-HY-101931-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101931-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HVEGF-IN-1, a quinazoline derivative, could specifically bind to the G-rich sequence in the internal ribosome entry site A (IRES-A) and destabilize the G-quadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM in SPR experiments. hVEGF-IN-1 could hinder tumor cells migration and repress tumor growth by decreasing VEGF-A protein expression[1].
CAS Number
1637443-98-1
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hVEGF-IN-1.html
Purity
99.26
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CCN(CC)CCOC(C=C1)=CC=C1NC2=NC(C3=C(NC(CCN4CCN(C)CC4)=O)C=CC=C3)=NC5=CC=CC=C52
Molecular Formula
C34H43N7O2
Molecular Weight
581.75
References & Citations
[1]Wang SK, et, al. Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents. J Med Chem. 2017 Jul 13;60 (13) :5306-5319.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

hVEGF-IN-1
CAS Number1637443-98-1
PubChem CID131704486
IUPAC NameN-[2-[4-[4-[2-(diethylamino)ethoxy]anilino]quinazolin-2-yl]phenyl]-3-(4-methylpiperazin-1-yl)propanamide
Molecular FormulaC34H43N7O2
Molecular Weight581.8
XLogP4.8
Topological Polar Surface Area85.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count13
Heavy Atom Count43
Formal Charge0
Complexity813
SMILES
CCN(CC)CCOC1=CC=C(C=C1)NC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4NC(=O)CCN5CCN(CC5)C
InChI
InChI=1S/C34H43N7O2/c1-4-40(5-2)24-25-43-27-16-14-26(15-17-27)35-33-29-11-7-9-13-31(29)37-34(38-33)28-10-6-8-12-30(28)36-32(42)18-19-41-22-20-39(3)21-23-41/h6-17H,4-5,18-25H2,1-3H3,(H,36,42)(H,35,37,38)
InChIKey
VIBJAHJNWHZSJP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of hVEGF-IN-1
CAS: 1637443-98-1
CID: 131704486
Formula: C34H43N7O2
MW: 581.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight581.8
XLogP34.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count13
Exact Mass581.34782364
Monoisotopic Mass581.34782364
Topological Polar Surface Area85.9 Ų
Heavy Atom Count43
Formal Charge0
Complexity813
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-148316HVEGF-IN-2
HY-160811-01HVEGF-IN-3
HY-N6838-011,1,1,1-Kestohexaose
HY-157129AMPK-α1β1γ1 activator 1
HY-1336231,1,1-Tribromoacetone
HY-149536TWIK-1/TREK-1-IN-1
HY-W160628S1,1,1-Trimethoxypropane-d5
HY-133630-011-Bromo-1,1-dichloroacetone
HY-1336291,1,1,3-Tetrachloroacetone
HY-W881439-011- (1,1-Dimethylethyl) tridecanedioate

Alternative Products

CatalogName
BA9041-50hVEGF-IN-1
A19518-5HVEGF-IN-1 5mg
A19518-10HVEGF-IN-1 10mg
A19518-50HVEGF-IN-1 50mg
A19518-1HVEGF-IN-1 1mg
A19518-200HVEGF-IN-1 200mg
A19518-100HVEGF-IN-1 100mg
A19518-25HVEGF-IN-1 25mg
GTR19236946-01HVEGF-IN-3
C8417-1hVEGF-IN-2

Popular Products