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HVEGF-IN-2

CAT: 0804-HY-148316Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148316Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HVEGF-IN-2 (compound 19) is a selective VEGF (Flk-1) receptor tyrosine kinases (RTK) inhibitor with an IC50 value of 2.5 μM. hVEGF-IN-2 inhibits PDGF RTK activity with an IC50 value of 33.1 μM. hVEGF-IN-2 can be used for the development of RTK-specific agents[1].
CAS Number
186610-88-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hvegf-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N4CCOCC4)C=C3
Molecular Formula
C19H18N2O2
Molecular Weight
306.36
Precautions
H302, H315, H319
References & Citations
[1]Sun L, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41 (14) :2588-603.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR1/Flt-1

Chemical Information

3-(4-Morpholinobenzylidene)indolin-2-one
CAS Number186610-88-8
PubChem CID2379240
IUPAC Name(3Z)-3-[(4-morpholin-4-ylphenyl)methylidene]-1H-indol-2-one
Molecular FormulaC19H18N2O2
Molecular Weight306.4
XLogP2.6
Topological Polar Surface Area41.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity462
SMILES
C1COCCN1C2=CC=C(C=C2)/C=C\3/C4=CC=CC=C4NC3=O
InChI
InChI=1S/C19H18N2O2/c22-19-17(16-3-1-2-4-18(16)20-19)13-14-5-7-15(8-6-14)21-9-11-23-12-10-21/h1-8,13H,9-12H2,(H,20,22)/b17-13-
InChIKey
FWFISWZSIAJQSO-LGMDPLHJSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-Morpholinobenzylidene)indolin-2-one
CAS: 186610-88-8
CID: 2379240
Formula: C19H18N2O2
MW: 306.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight306.4
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass306.136827821
Monoisotopic Mass306.136827821
Topological Polar Surface Area41.6 Ų
Heavy Atom Count23
Formal Charge0
Complexity462
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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