Products for Research Use Only
RegisterLogin

BQ-123 (TFA)

CAT: 0804-HY-12378ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-12378ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BQ-123 TFA is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 TFA inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension[1][2][3].
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bq-123-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@](C(N(CCC1)[C@]1([H])C2=O)=O)([H])CC(O)=O)[C@H](NC([C@@H](NC([C@H](N2)C(C)C)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C34.OC(C(F)(F)F)=O
Molecular Formula
C33H43F3N6O9
Molecular Weight
724.72
References & Citations
[1]Ihara M, et al. In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S11-S14.|[2]Sakamoto A, et al. Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J Biol Chem. 1993 Apr 25;268 (12) :8547-53.|[3]Zamora MA, et al. BQ123, an ETA receptor antagonist, inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 1993;9 (4) :429-433.|[4]Douglas SA, et al. BQ-123, a selective endothelin subtype A-receptor antagonist, lowers blood pressure in different rat models of hypertension. J Hypertens. 1994;12 (5) :561-567.|[5]Erdogan H et al. The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats. Hum Exp Toxicol, 2014 Oct, 33 (10) :1008-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
ETA

Related Products

CatalogName
HY-12378-01BQ-123
HY-P1016BQ-3020
HY-15894A-01BQ-788
HY-135446BQ-610
HY-P1016B-01BQ-3020 (ammonium)
HY-15894-01BQ-788 (sodium salt)
HY-P11354THR-123
HY-D0816-01Rhodamine 123
HY-162891EGFR-IN-123
HY-120406PLS-123

Alternative Products

CatalogName
MBS5815932BQ-123 TFA
GTR19036560-01BQ-3020 TFA
M30404BQ-3020 TFA (143113-45-5 free base)
B6626-5BQ-123
A15912-100BQ-123 100mg
A15912-10BQ-123 10mg

Popular Products