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GPR183 antagonist-3

CAT: 0804-HY-157939-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157939-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GPR183 antagonist-3 (compound 33) is an oral active GPR183 antagonist with the IC50 of 8.7 μM. GPR183 antagonist-3 displays strong in vitro antimigration and anti-inflammatory activity in monocytes, and improves the pathological symptoms of DSS-induced experimental colitis[1].
UNSPSC
12352005
Target
EBI2/GPR183
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gpr183-antagonist-3.html
Purity
98.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
BrC1=CC=C(C=C1)/C=C/C(N2CCN(CC2)C(C3=CC=C4N=C(SC4=C3)N)=O)=O
Molecular Formula
C21H19BrN4O2S
Molecular Weight
471.37
References & Citations
[1]Zeng R, et al. Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[d]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD) . J Med Chem. Published online February 28, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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