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GPR183 antagonist-2

CAT: 0931-T86519-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T86519-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2924063-98-7
Target
EBI2/GPR183
Related Pathways
GPCR/G Protein
Bioactivity
GPR183 antagonist-2 (compound 32), a selective antagonist of GPR183, exhibits excellent water solubility and pharmacokinetic properties. This compound effectively diminishes paw and joint swelling, and reduces gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a dose-dependent manner within a collagen-induced arthritis (CIA) mouse model. GPR183 antagonist-2 is applicable in researching autoimmune diseases [1].
Smiles
C(=C/C(=O)N1CCN(C(=O)C=2C=NC(OC)=NC2)CC1)\C=3C=C4C(=CC3)OC(F)(F)O4
Molecular Formula
C20H18F2N4O5
Molecular Weight
432.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

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HY-162011-01GPR183 antagonist-2
GTR19261950-01GPR183 antagonist-3
TBI5280-5MGML401, EBI2 (GPR183) antagonist
GTR19236543-01GPR183-IN-2
K0900403GPR183 sgRNA CRISPR Lentivector (Human) (Target 2)
K6166803Gpr183 sgRNA CRISPR Lentivector (Rat) (Target 2)
K4405503Gpr183 sgRNA CRISPR Lentivector (Mouse) (Target 2)
170684GPR183 (GPR183, EBI 2, EBI2, EBV-induced Gene 2, G-Protein-Coupled Receptor 183, G-Protein Coupled Receptor 183)
K4405507Gpr183 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
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