SB-366791

• Description :

  SB-366791 is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (IC50=5.7 nM) . SB-366791 can be used for the research of inflammation[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  TRP Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/SB-366791.html

• Purity :

  98.11

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(NC1=CC=CC(OC)=C1)/C=C/C2=CC=C(Cl)C=C2

• Molecular Formula :

  C16H14ClNO2

• Molecular Weight :

  287.74

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Lappin SC, et al. TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. Eur J Pharmacol. 2006;540 (1-3) :73-81.|[2] Gunthorpe MJ, et al. Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist [published correction appears in Neuropharmacology. 2004 May;46 (6) :905]. Neuropharmacology. 2004;46 (1) :133-149.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TRPV1

• CAS Number :

  [472981-92-3]