SB-366791

• Description:

  SB-366791 is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (IC50=5.7 nM) . SB-366791 can be used for the research of inflammation[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/SB-366791.html

• Purity:

  98.11

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(NC1=CC=CC(OC)=C1)/C=C/C2=CC=C(Cl)C=C2

• Molecular Formula:

  C16H14ClNO2

• Molecular Weight:

  287.74

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Lappin SC, et al. TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. Eur J Pharmacol. 2006;540 (1-3) :73-81.|[2] Gunthorpe MJ, et al. Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist [published correction appears in Neuropharmacology. 2004 May;46 (6) :905]. Neuropharmacology. 2004;46 (1) :133-149.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TRPV1

• CAS Number:

  [472981-92-3]